Osteoarthritis of the elbow joint secondary to elbow dysplasia is common in dogs. Intraarticular radionuclide injection is thought to suppress both synovitis and inflammatory pain mediators in the joint which are not directly addressed by current treatments.
Clinical effectiveness and safety of intraarticular administration of a 117mTin radiocolloid (Synovetin OATM) for treatment of early and intermediate grade osteoarthritis of the elbow in a dose-finding study conducted in 44 dogs
Minimal clinically-important differences for the 'Liverpool Osteoarthritis in Dogs' (LOAD) and the 'Canine Orthopedic Index' (COI) client-reported outcomes measures
Client-reported outcomes measures (CROMs) have been previously validated for the evaluation of canine osteoarthritis.
A multiple-session mesotherapy protocol for the management of hip osteoarthritis in police working dogs
Objective: To describe the effect of a mesotherapy protocol in dogs with osteoarthritis.
Animals: 30 dogs.
Homing of radiolabelled xenogeneic equine peripheral blood-derived MSCs towards a joint lesion in a dog
Osteoarthritis (OA) is a highly prevalent condition in dogs, causing a substantial reduction in quality of life and welfare of the animals. Current disease management focusses on pain relief but does not stop the progression of the disease. Therefore, mesenchymal stem cells (MSCs) could offer a promising disease modifying alternative. However, little is known about the behavior and the mode of action of MSCs following their administration.
Sustained release of locally delivered celecoxib provides pain relief for osteoarthritis: a proof of concept in dog patients
Objective: Drug delivery platforms that allow for gradual drug release after intra-articular administration have become of much interest as a treatment strategy for OA. The aim of this study was to investigate the safety and efficacy of an intra-articular sustained release formulation containing celecoxib (CXB), a COX-2 selective inhibitor.
This study aims to develop a comprehensive and easily executable histopathologic grading scheme for murine knee osteoarthritis (OA) using specific scoring criteria for both cartilage and periarticular changes, which may overcome important limitations of the existing grading systems.
Analgesic effects and arthritic changes following tramadol administration in a rat hip osteoarthritis model
We investigated the analgesic effects of tramadol and the arthritic changes following tramadol administration in the rat hip osteoarthritis (OA) model using mono-iodoacetate (MIA).
Defining the rate of, and factors influencing, radiographic progression of osteoarthritis of the canine hip joint
Background: This study aimed to define the rate of progression of radiographic osteoarthritis (OA) of the canine hip joint and to describe factors affecting this progression.
Intra-articular Injections With Either Triamcinolone Hexacetonide, Stanozolol, Hylan G-F 20, or a Platelet Concentrate Improve Clinical Signs in Police Working Dogs With Bilateral Hip Osteoarthritis
Objectives: To compare the effect of intra-articular treatment with triamcinolone hexacetonide (TH), stanozolol, hyaluronan, and a platelet concentrate in police working dogs with bilateral hip osteoarthritis (OA).
Study Design: Prospective, longitudinal, double-blinded, negative controlled study.
Sample Population: Fifty police working dogs with naturally occurring hip OA.
Practical relevance: An understanding of the process of musculoskeletal ageing - which all senior and geriatric cats will experience - is vital to maintaining the health and welfare of our ageing cat population.