Antibiotic delivery

Authors: Leslie A. Thomas DVM, Tatiana Bizikova MSc, Anne C. Minihan DVM, Diplomate ACVS
Journal: Veterinary Surgery

Objective: To characterize the in vitro elution and bioactivity of 2 formulations of antibiotics in a novel, dissolvable, cross-linked dextran polymer matrix: Formulation 1—amikacin and clindamycin (AC); Formulation 2—amikacin, clindamycin, and vancomycin (ACV).

Study Design: Prospective, in vitro, experimental study.

Authors: Stephane B. Alkabes, DVM; Stephen B. Adams, DVM, MS; George E. Moore, DVM, PhD; Kira C. Alkabes, DVM
Journal: American Journal of Veterinary Research

Objective—To determine whether joint lavage performed simultaneously with IV regional limb perfusion (IVRLP) reduces the effectiveness of IVRLP and to compare 2 types of tourniquets used for this procedure in horses.

Animals—11 adult horses.

Authors: L. A. Baez, C. Langston, S. Givaruangsawat, R. McLaughlin
Journal: Veterinary and Comparative Orthopaedics and Traumatology

Objectives: To determine the elution properties of meropenem and to compare the elutions of meropenem-impregnated polymethylmethacrylate (PMMA) beads without sterilization (P-M-C) to those sterilized with steam (P-M-A) and ethylene oxide gas (P-M-EO). Methods: A commercial bead mould was used to produce four groups of beads: one group without antibiotic (negative control), and three groups of meropenem-impregnated beads: P-M-C, P-M-A, and P-M-EO. The beads were placed in a phosphate buffered solution and eluent samples were collected.

Authors: David G. Levine DVM, Diplomate ACVS, Kira L. Epstein DVM, Diplomate ACVS, Ben J. Ahern BVSc, Dean W. Richardson DVM, Diplomate ACVS
Journal: Veterinary Surgery

Objective: To determine (1) if clinically useful concentrations of amikacin sulfate can be obtained in synovial fluid during regional limb perfusion (RLP) performed above the carpus in standing sedated horses and (2) to determine the efficacy of 3 tourniquet types (narrow rubber [NR], wide rubber [WR], pneumatic [PN]).

Animals: Horses (n=9).

Authors: Aylin Atilla VMD, MS, Harry W. Boothe DVM, MS, Diplomate ACVS, Melissa Tollett BS, Sue Duran BS, MS, PhD, Dubraska Campos Diaz DVM, MS, Jameson Sofge BS, Dawn M. Boothe DVM, PhD, Diplomate ACVIM & ACVCP
Journal: Veterinary Surgery

Objective: To describe in vitro elution characteristics of amikacin and vancomycin from calcium sulfate hemihydrate 98% (plaster of Paris, POP) beads and characterize eluent inhibition of Staphylococcus spp.

Study Design: Experimental study.

Authors: Russell A. Parker, BVSc , Bruce M. Bladon, BVM&S, DESTS, Diplomate ECVS , Kate McGovern, BvetMed , and Ken C. Smith, BVM&S, FRCPath, FRCVS
Journal: Veterinary Surgery

Objective: To describe and discuss previously unreported complications associated with intraosseous perfusion with gentamicin in horses.

Study Design: Case report.

Animals: Ten-year-old Warmblood gelding.

Methods: Intraosseous perfusion with gentamicin into the proximal phalanx (P1) was used as part of the treatment regimen for distal interphalangeal joint and navicular bursa synovial sepsis. Although the sepsis responded favorably complications developed at the perfusion site, including persistent osteomyelitis, progressive osteonecrosis, and ultimately pathologic fracture of P1.

Authors: L. V. SCHNABEL, M. G. PAPICH † , A. E. WATTS and L. A. FORTIER*
Journal: Equine Veterinary Journal

Reasons for performing study: Tetracycline compounds have been used to slow the progression of osteoarthritis (OA) and rheumatoid arthritis but the concentration of doxycycline attained in synovial fluid following oral, low-dose administration has yet to be determined.

Objective: To determine the concentration of doxycycline in synovial fluid following oral, low-dose administration.

Authors: G. Kelmer, DVM, MS, DACVS, C. T. Catasus, BS, A. M. Saxton, PhD and S. B. Elliot, BS
Journal: Veterinary Record

The feasibility of maintaining indwelling intravenous catheters in the saphenous, cephalic or palmar digital vein of horses for seven days to infuse antimicrobial drugs was investigated in 18 horses. The horses were randomly assigned to six groups according to the vein catheterised and whether they received amikacin or erythromycin. None of the catheters was replaced more than once, and 11 of the 18 catheters remained patent for all seven days. Neither the drug administered nor the vein catheterised significantly affected the survival of the catheter.

Authors: David G. Levine, DVM; Kira L. Epstein, DVM; Dana A. Neelis, DVM; Michael W. Ross, DVM
Journal: American Journal of Veterinary Research

Objective—To determine whether topical application of 1% diclofenac sodium cream would decrease inflammation at sites of IV regional limb perfusion (IVRLP) in healthy horses.

Animals—6 healthy adult horses (12 forelimbs).

Journal: Veterinary Surgery

Objective—To report the minimum inhibitory concentration (MIC) of amikacin sulfate for equine clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and characterize the initial kill and duration of the postantibiotic effect (PAE) for selected strains.

Study Design—Experimental study.