Antibiotic delivery

In Vitro and In Vivo Evaluation of Ferric-Hyaluronate Implants for Delivery of Amikacin Sulfate to the Tarsocrural Joint of Horses

Authors: NICOLA C. CRIBB, VetMB, DVSc, Diplomate ACVS , LUDOVIC P. BOURÉ, DMV, MSc, Diplomate ACVS , W. J. BRAD HANNA, DVM, PhD , MARGARETE K. AKENS, Dr med vet, PhD , SHAWN E. MATTSON, DVM, DVSc, Diplomate ACVS , GABRIELLE J. MONTEITH, BSc, J. SCOTT WEESE

Journal: Veterinary Surgery

Objective—To assess the antimicrobial elution characteristics, toxicity, and antimicrobial activity of amikacin-impregnated ferric-hyaluronate implants (AI-FeHAI) for amikacin delivery to the tarsocrural joint of horses. Study Design—Experimental study. Sample Population—AI-FeHAI implants, equine cartilage, and synovium, and horses (n=6). Methods— In vitro study: Five AI-FeHAI were placed in saline solution with daily replacement until implant degradation. Eluent was tested for amikacin concentration and bioactivity.

Category: Antibiotic delivery - Equine

Comparison of two indirect techniques for local delivery of a high dose of an antimicrobial in the distal portion of forelimbs of horses

Authors: Jason A. Errico, DVM; Troy N. Trumble, DVM, PhD; Aloisio C. D. Bueno, MV, MS; Jennifer L. Davis, DVM, PhD; Murray P. Brown, DVM, MSc

Journal: American Journal of Veterinary Research

Objective-To compare isolated limb retrograde venous injection (ILRVI) and isolated limb infusion (ILI) for delivery of amikacin to the synovial fluid of the distal interphalangeal and metacarpophalangeal joints and to evaluate the efficacy of use of an Esmarch tourniquet in standing horses.Animals-6 healthy adult horses.

Category: Antibiotic delivery